✦ LIBER ✦

Zinc transcription factors in cellular differentiation and organogenesis

✍ Scribed by Kenneth H. Falchuk

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 55 KB
Volume: 11
Category: Article
ISSN: 0896-548X
DOI: 10.1002/(sici)1520-670x(1998)11:2/3<89::aid-jtra3>3.0.co;2-#

No coin nor oath required. For personal study only.

✦ Synopsis

Zinc is a central component of the machinery involved with gene expression and its regulation. It affects the template function of DNA in chromatin, it is essential to the activity of RNA polymerases, determines the transcriptional rate itself, the types of mRNA transcripts synthesized and, ultimately, the types of proteins formed by a cell. A major mechanism for zinc regulation of gene expression is the interaction of the metal with the DNA binding domains of transcription factors required for cellular differentiation and developmental processes involved with organogenesis. Alterations in the formation and/or function of these zinc transcription factors, therefore, may account for the proliferative arrest and teratology induced zinc deficiency. The Xenopus laevis embryo system can be utilized to examine the role of zinc transcription factors in organogenesis.

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