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Zinc-specific response in metallothionein induction in liver of tumor-bearing mice

✍ Scribed by Atsushi Takeda; Kazuhiko Goto; Tetsu Sato; Haruna Tamano; Shoji Okada

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 67 KB
Volume: 10
Category: Article
ISSN: 0896-548X
DOI: 10.1002/(sici)1520-670x(1997)10:4<243::aid-jtra5>3.0.co;2-a

No coin nor oath required. For personal study only.

✦ Synopsis

The response of trace metals to host liver in tumor-bearing mice was studied based on the data that an increase of hepatic zinc metallothionein (Zn-MT) was correlated with tumor growth rates. Zn concentration and 65 Zn uptake in liver, unlike pancreas, were elevated 9 days after tumor transplantation. When zinc sulfate was subcutaneously (s.c.) injected into the tumor-bearing mice, hepatic MT, unlike pancreatic MT, was induced dose-dependently and much more than that in control mice. In the case of s.c. injection with cadmium chloride or copper chloride, however, hepatic MT in both control and tumor-bearing mice was induced dose-dependently. Yet, the induction efficiency by these two metals was nearly the same between control and tumor-bearing mice. These results indicate the unique response to exogenous Zn in host liver of tumor-bearing mice. An efficient induction of hepatic MT by Zn may lead to a retention of Zn in liver of tumor-bearing mice.

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