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Zinc finger nuclease-mediated transgene deletion

✍ Scribed by Joseph F. Petolino; Andrew Worden; Krisi Curlee; James Connell; Tonya L. Strange Moynahan; Cory Larsen; Sean Russell


Book ID
106498533
Publisher
Springer
Year
2010
Tongue
English
Weight
928 KB
Volume
73
Category
Article
ISSN
0167-4412

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The ability to achieve site-specific manipulation of the mammalian genome has widespread implications for basic and applied research. Gene targeting is a process in which a DNA molecule introduced into a cell replaces the corresponding chromosomal segment by homologous recombination, and thus presen