✦ LIBER ✦

Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease

✍ Scribed by Saskia Biskup; Andrew B. West

Book ID: 116270692
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 250 KB
Volume: 1792
Category: Article
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2008.09.015

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Lrrk2pathogenic substitutions in Parkins

Lrrk2pathogenic substitutions in Parkinson's disease

✍ Ignacio F. Mata; Jennifer M. Kachergus; Julie P. Taylor; Sarah Lincoln; Jan Aasl 📂 Article 📅 2005 🏛 Springer 🌐 English ⚖ 415 KB

Pathogenicity of LRRK2 P755L variant in

Pathogenicity of LRRK2 P755L variant in Parkinson's disease

✍ Eng-King Tan; Hui-Qin Lim; Yih Yuen; Yi Zhao 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB

## Abstract A heterozygous 2264C→T variant (P755L) in __LRRK2__ gene has been reported to be a likely pathogenic variant among ethnic Chinese patients with Parkinson's disease (PD). In a case control study, we performed genetic analysis of the P755L variant in an independent cohort of Chinese patie

Novel pathogenic LRRK2 p.Asn1437His subs

Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease

✍ Jan O. Aasly; Carles Vilariño-Güell; Justus C. Dachsel; Philip J. Webber; Andrew 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 608 KB

## Abstract Genealogical investigation of a large Norwegian family (F04) with autosomal dominant parkinsonism has identified 18 affected family members over four generations. Genetic studies have revealed a novel pathogenic __LRRK2__ mutation c.4309 A>C (p.Asn1437His) that co‐segregates with diseas

Pathogenicity of the Lrrk2 R1514Q substi

Pathogenicity of the Lrrk2 R1514Q substitution in Parkinson's disease

✍ Mathias Toft; Ignacio F. Mata; Owen A. Ross; Jennifer Kachergus; Mary M. Hulihan 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB

## Abstract An increasing number of nonsynonymous __LRRK2__ variants are being reported as putative pathogenic mutations. We identified one large kindred harboring the Lrrk2 R1514Q substitution; however, the variant did not segregate fully with disease. Combined analyses of three case–control serie

LRRK2 in Parkinson’s disease: biochemica

LRRK2 in Parkinson’s disease: biochemical functions

✍ Vasanti S. Anand; Steven P. Braithwaite 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 399 KB

LRRK2 and Parkinson’s disease in Norway

✍ M. Toft; K. Haugarvoll; O. A. Ross; M. J. Farrer; J. O. Aasly 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB