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ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive disease

โœ Scribed by Shroyer, Kenneth R; Horwitz, Kathryn B; Broaddus, Russell R; Singh, Meenakshi; Spoelstra, Nicole S; Jean, Annie; Howe, Erin; Torkko, Kathleen C; Clark, Hilda R; Darling, Douglas S


Book ID
109887707
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
724 KB
Volume
21
Category
Article
ISSN
0893-3952

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Transforming growth factor-b (TGF-b1) is a potent negative regulator of cell growth that transduces signals through interactions with type I and II receptors. Abnormal expression and mutational alterations of these receptors have been observed in several human malignancies. In this study, we investi