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ZD9583, an Orally Effective Thromboxane A2 Synthase Inhibitor and Receptor Antagonist with a Sustained Duration of Action in Rat and Dog

✍ Scribed by R. P. BROWNLIE; N. J. BROWNRIGG; H. M. BUTCHER; R. GARCIA; R. JESSUP; V. J. LEE; S. TUNSTALL; M. G. WAYNE


Book ID
118110639
Publisher
Pharmaceutical Press
Year
1997
Tongue
English
Weight
739 KB
Volume
49
Category
Article
ISSN
2042-7158

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Picotamide (G 137), a new non prostanoid inhibitor of in vitro arachidonic acid induced platelet aggregation, has been further characterized in in vitro and ex vivo studies. When whole blood was activated with collagen in the presence of picotamide 5 x 10(-4) M, thromboxane B2 production was decreas