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ZD6474 reverses multidrug resistance by directly inhibiting the function of P-glycoprotein

✍ Scribed by Freshney, R I

Book ID
109999332
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
35 KB
Volume
97
Category
Article
ISSN
0007-0920

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✍ Praveen Elamanchili; Cyrus McEachern; Helen Burt πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 331 KB

Overexpression of P-glycoprotein (Pgp) is one of the major limitations in cancer chemotherapy. Previous work has shown that amphiphilic diblock copolymers composed of methoxypolyethylene glycol-block-polycaprolactone (MePEG-b-PCL) diblock copolymers enhanced the cellular accumulation of Pgp substrat