## Abstract Purpose: The epidermal growth factor receptor (EGFR) autocrine pathway plays an important role in cancer cell growth. Vascular endothelial growth factor A (VEGF‐A) is a key regulator of tumor‐induced endothelial cell proliferation and vascular permeability. ZD6474 is an orally available
✦ LIBER ✦
ZD6474 – a novel inhibitor of VEGFR and EGFR tyrosine kinase activity
✍ Scribed by Ryan, A J; Wedge, S R
- Book ID
- 109998524
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 189 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0007-0920
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## Abstract ZD6474 is a vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. The present study was undertaken to investigate the direct antiproliferative effect of ZD6474 on human nasopharyngeal carcinoma (NPC) __in vitro__ and t
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