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Zamamistatin, a significant antibacterial bromotyrosine derivative, from the Okinawan sponge Pseudoceratina purpurea

✍ Scribed by Noboru Takada; Reiko Watanabe; Kiyotake Suenaga; Kaoru Yamada; Katsuhiro Ueda; Masaki Kita; Daisuke Uemura


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
113 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis


Zamamistatin was isolated from the Okinawan sponge Pseudoceratina purpurea. It was determined to be a novel bromotyrosine derivative by careful analysis of 2D NMR spectra and comparison of its 1 H NMR spectrum with those of structurally related compounds. The absolute stereostructure of zamamistatin was determined by the modified Mosher's method. Zamamistatin exhibited significant antibacterial activity against Rhodospirillum salexigens, which has adhering properties.


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