Yolk-sac carcinoma of extra-embryonic origin in the 129 Sv/Sl mouse

✍ Scribed by Halina Sobis; Luc Van Hove; Michel Vandeputte

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: French
• Weight: 884 KB
• Volume: 32
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910320317

✦ Synopsis

Abstract

Displacement of the visceral yolk‐sac in fetectomized rats and hamsters does not only induce benign teratomas but may also lead to the development of malignant yolksac carcinoma. In the mouse, displacement of this extraembryonic membrane readily induces teratoma but until now yolk‐sac carcinoma has never been observed in this species. In the present study we report the development of yolk‐sac carcinoma in 129 Sv/Sl mice after a long latent period (8 months). The tumor is composed of visceral and parietal patterns in the primary neoplasm and in its metastases. It develops from the extra‐embryonal part belonging to normal (+/+), heterozygous (SI/+) or sterile (SI/SI) embryos, which proves that these yolk‐sac carcinomas are not of germ‐cell origin.