Yohimbine-induced seizures in mice: A model predictive of potential anxiolytic and GABA-mimetic agents

The potential of sphingomyelin as a chem

The potential of sphingomyelin as a chemopreventive agent in AOM-induced colon cancer model: wild-type and p53+/– mice

✍ Ying Hu; Richard K. Le Leu; Damien Belobrajdic; Graeme P. Young 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 399 KB

## Abstract A protective effect of sphingolipids on colorectal cancer (CRC) has been reported in certain mouse strains. It is unknown if sphingolipids are protective in a __p53__ deficiency mouse model of CRC. This study investigated the effect of sphingomyelin (SM) on intestinal sphingomyelinase (