Yield of endoscopic ultrasound-guided fine-needle aspiration biopsy in patients with suspected pancreatic carcinoma

✍ Scribed by Eloubeidi, Mohamad A. ;Jhala, Darshana ;Chhieng, David C. ;Chen, Victor K. ;Eltoum, Isam ;Vickers, Selwyn ;Mel Wilcox, C. ;Jhala, Nirag

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 241 KB
• Volume: 99
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/cncr.11643

✦ Synopsis

BACKGROUND.

Although atypical or suspicious cytology may support a clinical diagnosis of a malignancy, it is often not sufficient for the implementation of therapy in patients with pancreatic carcinoma. Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) is a relatively new method for obtaining cytology samples, and one that may decrease the number of atypical/suspicious diagnoses. The goals of the current study were to prospectively evaluate the yield of EUS-FNAB in the diagnosis of patients presenting with solid pancreatic lesions and to evaluate the significance of atypical, suspicious, and false-negative aspirates.

METHODS.

All patients who presented with a solid pancreatic lesion and underwent EUS-FNAB over a 13-month period were included in the current study. One endoscopist performed all EUS-FNABs. On-site evaluation of specimen adequacy by a cytopathologist was available for each case. Follow-up included histologic correlation (n ϭ 21) and clinical and/or imaging follow-up (n ϭ 80), including 38 patients who died of the disease.