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Yeast mutants affecting the spontaneous mutation frequency on both the mitochondrial and nuclear genomes

✍ Scribed by Leland H. Johnston; Anthony L. Johnson

Book ID
113192517
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
500 KB
Volume
109
Category
Article
ISSN
0027-5107

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We have isolated about five hundred temperature-sensitive mutants specific for the mitochondrial functions. Their growth on glycerol is defective at 36 degrees C and/or 20 degrees C. While most of the mutations were nuclearly inherited, about thirty were found to be of mitochondrial origin. 1) Four

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1. Several nuclear mutants have been isolated which showed thermo- or cryo-sensitive growth on non-fermentable media. Although the original strain carried mitochondrial drug resistance mutations (CR, ER, OR and PR), the resistance to one or several drugs was suppressed in these mutants. Two of them