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Yeast mutant, rna1, affects the entry into polysomes of ribosomal RNA as well as messenger RNA

โœ Scribed by Petersen, Nancy S. ;Nierlich, Donald P.


Publisher
Springer
Year
1978
Tongue
English
Weight
346 KB
Volume
162
Category
Article
ISSN
0026-8925

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โœฆ Synopsis


The entry of newly labeled ribosomal subunits and mRNA into polysomes was examined in the yeast mutant rna1. The entry of both types of RNA into polysomes is inhibited rapidly at the restrictive temperature. Analysis of the labeling of the ATP pool and the kinetics of synthesis and processing of mRNA at the restrictive temperature leads to the conclusion that the primary defect in the mutant affects transport of both ribosomes and messenger across the nuclear membrane.


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The rna2 mutation of yeast affects the p
โœ Teem, John L. ;Rodriguez, Jose R. ;Tung, Lin ;Rosbash, Michael ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 289 KB

The temperature sensitive rna2 mutation of Saccharomyces cerevisiae causes a rapid and dramatic decrease in the abundance of most ribosomal protein mRNAs We and others have recently shown that the processing of ribosomal protein mRNAs is defective at the nonpermissive temperature, suggesting that in