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Yeast cells as a tool for analysis of HIV-1 protease susceptibility to protease inhibitors, a comparative study

✍ Scribed by Ravaux, Isabelle; Perrin-East, Christelle; Attias, Coralie; Cottalorda, Jacqueline; Durant, Jacques; Dellamonica, Pierre; Gluschankof, Pablo; Stein, Andreas; Tamalet, Catherine

Book ID
121429634
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
235 KB
Volume
195
Category
Article
ISSN
0166-0934

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## Abstract We have developed a simple approach for the evaluation of the free energies of inhibitor binding to the protease of the human immunodeficiency virus (HIV‐1 PR). Our algorithm is based on the observation that most groups that line the binding pockets of this enzyme are hydrophobic in nat