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Yeast as a Model System to Study Drugs Effective against Apicomplexan Proteins

✍ Scribed by Carol Hopkins Sibley; Victoria Hertle Brophy; Sandie Cheesman; Kelly Lee Hamilton; Eleanor G. Hankins; Jason M. Wooden; Brian Kilbey


Book ID
115638831
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
756 KB
Volume
13
Category
Article
ISSN
1046-2023

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A protocol for the rapid energetic analysis of protein-ligand complexes has been developed. This protocol involves the generation of protein-ligand complex ensembles followed by an analysis of the binding free energy components. We apply this methodology toward understanding the origin of binding sp