Yamanaka factors critically regulate the
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Liu, Xiaosong; Huang, Jinyan; Chen, Taotao; Wang, Ying; Xin, Shunmei; Li, Jian;
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Article
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2008
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Nature Publishing Group
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English
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Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors regulate the developmental signaling network necessary for ES cell pluripotency. Howe