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Y chromosome loss in esophageal carcinoma: An in situ hybridization study

✍ Scribed by Stephen Hunter; Terry Gramlich; Karen Abbott; Vijay Varma

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
596 KB
Volume
8
Category
Article
ISSN
1045-2257

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✦ Synopsis

Carcinoma of the esophagus shows a strong male predominance and other epidemiologic differences from cancers arising at other sites. In this study, the prevalence of Y chromosome loss in 29 carcinomas of the esophagus and 53 carcinomas arising elsewhere in the aerodigestive tract was assessed by in situ hybridization of formalin-fixed paraffin-embedded tissue sections. Absence of the Y chromosome was defined as ( I ) negative staining for Y in neoplastic cells with positive staining for Y in immediately adjacent nonneoplastic epithelial and stromal cells, (2) positive staining of neoplastic cells with control probes for chromosomes X and 17, and (3) similar results at different stringencies and levels of protein digestion. According to these criteria, absence of the Y chromosome was observed in I3 of 14 (93%) adenocarcinomas of the esophagus, 8 of I3 (62%) squamous cell carcinomas of the esophagus, and 5 of 53 (9%) Carcinomas arising in other sites. For the neoplasms examined, Y chromosome deletion was strongly and selectively associated with carcinomas, particularly adenocarcinomas, of the esophagus (P <.OOOl). These findings suggest that Y chromosome loss may be pathogenetically significant in these neoplasms. Genes Chrom Cancer 8:/ 72-1 77(/993). 0 I993 Wiley-Liss, Inc.*

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