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X=Y-ZH systems as potential 1,3-dipoles. Part 47.1 tandem nucleophilic substitution-1,3 dipolar cycloaddition reactions of oximes with epoxides and dipolarophiles

✍ Scribed by Jasothara Markandu; H. Ali Dondas; Martyn Frederickson; Ronald Grigg


Book ID
108378735
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
567 KB
Volume
53
Category
Article
ISSN
0040-4020

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Tandem nucleophilic substitution - 1,3 d
✍ Ronald Grigg; Jasothara Markandu πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 195 KB

Regiospecific nucleophilic substitution reactions involving attack of the nitrogen atom of oximes on epoxides are used to generate nitrones which are then trapped in 1,3-dipolar cycloaddition reactions. These tandem processes are shown to be flexible and to have wide synthetic scope for the construc