PTEN: One Gene, Many Syndromes
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Charis Eng
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Article
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2003
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John Wiley and Sons
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English
β 217 KB
## Communicated by Christopher Mathew PTEN, on 10q23.3, encodes a major lipid phosphatase which signals down the phosphoinositol-3-kinase/Akt pathway and effects G1 cell cycle arrest and apoptosis. Germline PTEN mutations have been found to occur in 80% of classic Cowden syndrome (CS), 60% of Banna