𝔖 Bobbio Scriptorium
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XLP: One Gene, Many Players

✍ Scribed by Michael J. Czar; Pamela L. Schwartzberg


Book ID
115593834
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
29 KB
Volume
100
Category
Article
ISSN
1090-2341

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## Communicated by Christopher Mathew PTEN, on 10q23.3, encodes a major lipid phosphatase which signals down the phosphoinositol-3-kinase/Akt pathway and effects G1 cell cycle arrest and apoptosis. Germline PTEN mutations have been found to occur in 80% of classic Cowden syndrome (CS), 60% of Banna