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Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca2+pumps

✍ Scribed by P.De Smet; J.B. Parys; G. Callewaert; A.F. Weidema; E. Hill; H.De Smedt; C. Erneux; V. Sorrentino; L. Missiaen


Book ID
114483144
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
133 KB
Volume
26
Category
Article
ISSN
0143-4160

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✍ Elisabete Ferreiro; Catarina R. Oliveira; Cláudia Pereira 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB

## Abstract Studies with in‐vitro‐cultured neurons treated with amyloid‐β (Aβ) peptides demonstrated neuronal loss by apoptosis that is due, at least in part, to the perturbation of intracellular Ca^2+^ homeostasis. In addition, it was shown that an endoplasmic reticulum (ER)‐specific apoptotic pat