๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Xenopus oocyte maturation: new lessons from a good egg

โœ Scribed by James E. Ferrell Jr.

Book ID
101298387
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
132 KB
Volume
21
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

โœฆ Synopsis

Fully grown Xenopus oocytes can remain in their immature state essentially indefinitely, or, in response to the steroid hormone progesterone, can be induced to develop into fertilizable eggs. This process is termed oocyte maturation. Oocyte maturation is initiated by a novel plasma membrane steroid hormone receptor. Progesterone brings about inhibition of adenylate cyclase and activation of the Mos/MEK1/p42 MAP kinase cascade, which ultimately brings about the activation of the universal M phase trigger Cdc2/cyclin B. Oocyte maturation provides an interesting example of how signaling cascades entrain the cell cycle clock to environmental changes. Bio Essays 21:833-842, 1999.

1999 John Wiley & Sons, Inc.

1 ''Thy head is as full of quarrels as an egg is full of meat.''

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โœ James E. Ferrell Jr. ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 73 KB

Xenopus oocytes mature in response to the steroid hormone progesterone. At the level of a population of oocytes, the response is graded-the higher the concentration of progesterone, the larger the fraction of oocytes that will mature-but at the level of the individual oocyte, the response is all-or-