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Xenobiotics and the Glucocorticoid Receptor: Additive Antagonistic Effects on Tyrosine Aminotransferase Activity in Rat Hepatoma Cells

✍ Scribed by Maria Johansson; Niklas Johansson; Bert-Ove Lund

Book ID
111316008
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
151 KB
Volume
96
Category
Article
ISSN
1742-7835

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## Abstract The effects of actinomycin‐D and 3′‐deoxyadenosine (cordycepin) on the steroid‐mediated induction of tyrosine aminotransferase (TAT) synthesis have been reexamined in view of recent reports that the primary inhibitory action of these compounds may affect synthesis of proteins as well as

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## Abstract The increase in tyrosine aminotransferase activity which occurs in rat hepatoma tissue culture (HTC) cells in response to cyclic AMP analogs has been shown to be an enzyme induction, similar to the larger response observed in certain other hepatoma cells and in liver. A specific antibod