Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals
β Scribed by Rotroff, Daniel M.; Beam, Andrew L.; Dix, David J.; Farmer, Adam; Freeman, Kimberly M.; Houck, Keith A.; Judson, Richard S.; LeCluyse, Edward L.; Martin, Matthew T.; Reif, David M.; Ferguson, Stephen S.
- Book ID
- 120283049
- Publisher
- Taylor and Francis Group
- Year
- 2010
- Tongue
- English
- Weight
- 940 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1093-7404
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The culture of fetal hepatocytes for 64 h in medium supplemented with 5 mM glucose, T3, insulin, and dexamethasone resulted in the coordinate precocious expression of malic enzyme mRNA, protein, and specific activity. T3 was the main inducer; meanwhile, insulin exerted a small synergist
## Abstract Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drugβmetabolizing enzymes in these in vitro models, expression of genes coding for sev