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Xenobiotic inducible regions of the human arylamine N-acetyltransferase 1 and 2 genes

✍ Scribed by Kent R Mitchell; David Warshawsky

Book ID: 119537527
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 627 KB
Volume: 139
Category: Article
ISSN: 0378-4274
DOI: 10.1016/s0378-4274(02)00437-x

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## Abstract Sensitization to arylamines such as p-phenylenediamine is frequently diagnosed in patients with allergic contact dermatitis. Reactive metabolites of p-phenylenediamine might be produced in the skin by O-acetylation of N-hydroxylamines catalysed by local N-acetyltransferases (NATs). In t