Xanthine Oxidase Inhibitory Activity of Flavonoids and Tannins from Hexachlamys edulis (Myrtaceae)
✍ Scribed by G. Schmeda-Hirschmann; J. Zúñiga; M. Dutra-Behrens; G. Habermehl
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 260 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The acetone-water extract of Hexachlamys edulis (Myrtaceae) inhibited the enzyme xanthine oxidase (XO) in vilro. Bioassay-guided isolation led to the gallic acid ester in 2" of myricitrin (desmanthin-1), (-)-epigallocatechin-3-0-gallate (EGG) and pentagalloylglucose as the main XO inhibitors of H. edulis. Desmanthin-1 and EGG were mixed-type inhibitors of XO with Ki values of 1.6 x M and 1.8 x W4 M, respectively. Pentagalloylglucose was an uncompetitive XO inhibitor with a KFs, of 6.7 x M. From the active n-butanol soluble part of the aqueous acetone extract of H. edub, several flavonoids were isolated. The flavonoids were mainly myricetin-3-0monoglycosides with the quercetin glycoside avicularin as a minor compound displaying a weak inhibitory activity towards XO.