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Xanthan gum to tailor drug release of sustained-release ethylcellulose mini-matrices prepared via hot-melt extrusion: in vitro and in vivo evaluation

โœ Scribed by E. Verhoeven; C. Vervaet; J.P. Remon


Book ID
116437498
Publisher
Elsevier Science
Year
2006
Tongue
French
Weight
441 KB
Volume
63
Category
Article
ISSN
0939-6411

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Sustained-release and swelling character
โœ T. Quinten; T. De Beer; F. O. Onofre; G. Mendez-Montealvo; Y. J. Wang; J. P. Rem ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 419 KB

Sustained-release matrix tablets were developed by injection moulding using metoprolol tartrate (MPT) and ethylcellulose (EC) as sustained-release agent. Dibutyl sebacate was selected as plasticiser. The influence of matrix composition, plasticiser concentration, and drug load on drug release was ev