X-Ray Supramolecular Structure, NMR Spectroscopy and Synthesis of 3-Methyl-1-phenyl-1H-chromeno[4,3-c]pyrazol-4-ones Formed by the Unexpected Cyclization of 3-[1-(Phenyl-hydrazono)ethyl]-chromen-2-ones
✍ Scribed by Padilla-Martinez, Itzia I.; Flores-Larios, Irma Y.; García-Baez, Efren V.; Gonzalez, Jorge; Cruz, Alejandro; Martínez-Martinez, Francisco J.
- Book ID
- 121469489
- Publisher
- Molecular Diversity Preservation International
- Year
- 2011
- Tongue
- English
- Weight
- 428 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1420-3049
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## Abstract Nucleophilic addition of alkyl‐ and benzylthiols to benzoquinone diimine (**1**) gave the corresponding 3‐alkylthio‐ or 3‐benzylthio‐1,4‐phenylenediamines (**2**–**5**). However, addition of aryl‐ or heteroarylthiols to **1** formed 2‐arylthio‐ or 2‐heteroarylthio‐1,4‐phenylenediamines
## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des