✦ LIBER ✦
X-ray Photolysis To Release Ligands from Caged Reagents by an Intramolecular Antenna Sensitive to Magnetic Resonance Imaging
✍ Scribed by Morgane Petit; Guillaume Bort; Dr. Bich-Thuy Doan; Dr. Cécile Sicard; Dr. David Ogden; Prof. Daniel Scherman; Prof. Clotilde Ferroud; Dr. Peter I. Dalko
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 490 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
✦ Synopsis
However, the efficiency of Gd-DOTAGA-AQ is not high enough for direct long-term application in vivo. The lethal dosage (LD 50 ) of X-ray or g irradiation is at approximately 5 Gray for mice, suggesting that an improvement of sensitivity of three orders is needed for nonintrusive use. Given the apparent dependence of this mechanism on the energy dose alone, an improvement may best be achieved by generating multisite probes.