X-Ray Crystallographic and MO Studies on the Conformation of Corynoline and the Related Compounds
โ Scribed by Miyoko Kamigauchi; Yuko Noda; Narao Takao; Toshimasa Ishida; Masatoshi Inoue
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- German
- Weight
- 298 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0018-019X
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In an attempt to view the onset of urea denaturation in ribonuclease we have collected X-ray diffraction data on ribonuclease S crystals soaked in 0, 1.5, 2, 3, and 5 molar urea. At concentrations above 2 M urea, crystals were stabilized by glutaraldehyde crosslinking. We have also collected data on
## Abstract Valsartan (1), an antihypertensive drug of the sartan family, and three related compounds, 3โmethylโ2โ((2โฒโ(1โmethylโ1Hโtetrazolโ5โyl)biphenylโ4โylmethyl) pentanoylamino)butyric acid (2), 3โisopropylโ6โpropylโ4โ(2โฒโ(1Hโtetrazolโ5โyl)biphenylโ4โylmethyl) morpholineโ2,5โdione (3), and 3โi