X-Ray conformational study of hydrazino peptide analogues

✍ Scribed by André Aubry; Daniel Bayeul; Jean-Paul Mangeot; Joëlle Vidal; Sébastien Sterin; André Collet; Alain Lecoq; Michel Marraud

• Publisher: Wiley (John Wiley & Sons)
• Year: 1991
• Tongue: English
• Weight: 490 KB
• Volume: 31
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.360310625

✦ Synopsis

We have solved the crystal structures of nine pseudo-peptide analogues deriving from the hydrazino analogue of glycine or valine (NBH2-N"H-C"HR-C02H, R = H or i P r ) or proline ( NBH2-N"-C"H-C02H) and containing the hydrazide ( CO-NOH-N" <) or N@-Z-aminoamide [ CO-N"( NBHZ)] peptidomimetic link. This study gives access to the average geometry of these two links, to their inter-and intramolecular interaction modes, and to their influence on the conformational properties of the molecules.