WT1 proteins: functions in growth and differentiation
โ Scribed by Volkher Scharnhorst; Alex J van der Eb; Aart G Jochemsen
- Book ID
- 117520459
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 290 KB
- Volume
- 273
- Category
- Article
- ISSN
- 0378-1119
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Cell differentiation and four WT1 isoforms were assessed in CD34(+) cells from patients with acute myelogenous leukemia in presence or absence of recombinant human GM-CSF and G-CSF, on days 0, 10 and 20 of culture. We found that WT1 isoforms expression was consistently higher in AML-derived CD34+ ce
## Abstract In patients with acute leukemia, Wilms' tumor gene 1 (WT1) has been used as a target for the detection of minimal residual disease (MRD) by PCR techniques. The expression of WT1 protein, however, has not been extensively studied. To determine the relation between expression of WT1 trans