Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis
β Scribed by Thomas A Natoli; Julia A Alberta; Alex Bortvin; Mary E Taglienti; Douglas B Menke; Jan Loring; Rudolf Jaenisch; David C Page; David E Housman; Jordan A Kreidberg
- Book ID
- 116974828
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 785 KB
- Volume
- 268
- Category
- Article
- ISSN
- 0012-1606
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The germ cell lineage in mice becomes lineage-restricted about 7.2 days post coitum. Its progenitors have migrated from the proximal region of the epiblast. Cells from the distal region of the epiblast will also give rise to germ cells, if they are transplanted to the proximal region at the appropri
## Abstract The fetal and neonatal development of male germ cells (gonocytes) is a poorly understood but crucial process for establishing fertility. In rodents, gonocytes go through two phases of proliferation accompanied by apoptosis and separated by a quiescent period during the end of fetal deve