WRN mutations in Werner Syndrome
โ Scribed by Michael J. Moser; Junko Oshima; Raymond J. Monnat Jr.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 56 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1059-7794
No coin nor oath required. For personal study only.
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The International Registry of Werner syndrome (www.wernersyndrome.org) has been providing molecular diagnosis of the Werner syndrome (WS) for the past decade. The present communication summarizes, from among 99 WS subjects, the spectrum of 50 distinct mutations discovered by our group and by others
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## Abstract Werner syndrome is an autosomal inherited disease that is characterized by premature aging. The gene mutated in Werner syndrome (WS), __WRN__, encodes both a 3โฒโโโ5โฒ DNA helicase and a 3โฒโโโ5โฒ DNA exonuclease. Among the WS phenotypes is an exceptionally high incidence of sarcomas. We as
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