## Abstract Since our original demonstration of the metabolism of 1α,25(OH)~2~D~3~ into 1α,25(OH)~2~‐3‐epi‐D~3~ in human keratinocytes, there have been several reports indicating that epimerization of the 3 hydroxyl group of vitamin D compounds is a common metabolic process. Recent studies reported
✦ LIBER ✦
WR-2721 (WR): A potent hypocalcemic agent and inhibitor of parathyroid hormone secretion
✍ Scribed by D. Glover; S. Goldfarb; J.H. Glick
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 172 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0360-3016
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1␣,25(OH) 2 D 3 is an important negative regulator of parathyroid hormone (PTH) gene transcription. In parathyroid cells, as in other target tissues, 1␣,25(OH) 2 D 3 is degraded by side chain oxidation by the inducible 24-hydroxylase. We have previously shown that one metabolite of this pathway, 1␣,