Wound healing using a collagen matrix: Effect ofDC electrical stimulation

✍ Scribed by Dunn, Michael G. ;Doillon, Charles J. ;Berg, Richard A. ;Olson, Robert M. ;Silver, Frederick H.

• Book ID: 102874353
• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 946 KB
• Volume: 22
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820221310

✦ Synopsis

Rapid fibroblast ingrowth and collagen deposition occurs in a reconstituted type I collagen matrix that is implanted on fullthickness excised animal dermal wounds. The purpose of this study is to evaluate the effects of direct current stimulation on dermal fibroblast ingrowth using carbon fiber electrodes incorporated into a collagen sponge matrix. Preliminary results suggest that fibroblast ingrowth and collagen fi-ber alignment are increased in collagen sponges stimulated with direct currents between 20 and 100 PA. Maximum fibroblast ingrowth into the collagen sponge is observed near the cathode at a current of 100 PA. These results suggest that electrical Stimulation combined with a collagen matrix may be a method to enhance the healing of chronic dermal wounds.