✦ LIBER ✦

Would the real mccoy please stand up?

Book ID: 102237576
Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 289 KB
Volume: 19
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840190338

No coin nor oath required. For personal study only.

✦ Synopsis

Sera from patients with primary biliary cirrhosis (PBC) react with enzymes of the 2-0x0 dehydrogenase pathways, particularly PDC-E2. These enzymes are present in all nucleated cells, yet autoimmune damage is confined to biliary epithelial cells. Using a panel of eight mouse monoclonal antibodies and a human combinatorial antibody specific for PDC-E2, we examined by indirect immunofluorescence and confocal microscopy sections of liver from patients with PBC, progressive sclerosing cholangitis, and hepatocarcinoma The monoclonal antibodies gave typical mitochondrial immunofluorescence on biliary epithelium and on hepatocytes from patients with either PBC, progressive sclerosing cholangitis, or hepatocarcinoma. However, one of eight mouse monoclonal antibodies ((3355.1) and the human combinatorial antibody reacted with great intensity and specificity with the luminal region of biliary epithelial cells from patients with PBC. Simultaneous examination of these sections with an antiisotype reagent for human IgA revealed high IgA staining in the luminal region of biliary epithelial cells in patients with PBC. IgG and

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