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Workweek Optimization of Experimental Designs: Exact Designs for Variable Sampling Costs

โœ Scribed by Stephen E. Wright; Belle M. Sigal; A. John Bailer

Book ID
107693453
Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
486 KB
Volume
15
Category
Article
ISSN
1085-7117

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## Abstract We propose optimized twoโ€stage designs for genomeโ€wide caseโ€control association studies, using a hypothesis testing paradigm. To save genotyping costs, the complete marker set is genotyped in a subโ€sample only (stage I). On stage II, the most promising markers are then genotyped in the