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Wolfram syndrome 1 (Wfs1) gene expression in the normal mouse visual system

✍ Scribed by June Kawano; Yukio Tanizawa; Koh Shinoda


Book ID
118283085
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
412 KB
Volume
510
Category
Article
ISSN
0021-9967

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## Abstract Confocal laser scanning microscope image of double immunostaining for Wfs1 protein (green) and for glial fibrillary acidic protein (GFAP; an astrocyte marker; red) in the normal mouse retina and optic nerve. Cell nuclei are labeled in blue. The Wfs1 protein, also called wolframin, is th

Wolfram syndrome in French population: C
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Wolfram syndrome (WS), a rare autosomal recessive neurodegenerative disorder, results in most cases from mutations in the WFS1 gene. In this study, a total of 19 patients with Wolfram syndrome and 36 relatives from 17 families were screened for mutations in the WFS1 gene. WFS1 mutations were identif