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wnt3a but not wnt11 supports self-renewal of embryonic stem cells

โœ Scribed by Dinender K. Singla; David J. Schneider; Martin M. LeWinter; Burton E. Sobel


Book ID
116292880
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
476 KB
Volume
345
Category
Article
ISSN
0006-291X

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A role for Wnt signalling in self-renewa
โœ Reya, Tannishtha; Duncan, Andrew W.; Ailles, Laurie; Domen, Jos; Scherer, David ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 346 KB

Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to all lineages of the blood; however, the signals that regulate HSC self-renewal remain unclear. Here we show that the Wnt signalling pathway has an important role in this process. Overexpression of activated bet