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Wnt11/Wnt5a interaction increases canonical Wnt signaling activity

✍ Scribed by Sang-Wook Cha; Emmanuel Tadjuidje; James Wells; Christopher Mayhew; Janet Heasman

Book ID
116977589
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
119 KB
Volume
331
Category
Article
ISSN
0012-1606

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## Abstract Wnt proteins initiate signaling by binding to seven transmembrane spanning receptors of the frizzled (Fz) family together with the members of the low‐density lipoprotein receptor‐related protein (LRP) 5 and 6. A chimera of human Wnt3 and Fz1 receptor was developed that efficiently activ