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Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism

โœ Scribed by Tannishtha Reya; Mary O'Riordan; Ross Okamura; Erik Devaney; Karl Willert; Roel Nusse; Rudolf Grosschedl


Book ID
117722359
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
371 KB
Volume
13
Category
Article
ISSN
1074-7613

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Although the cytokine-inducible transcription factor signal transducer and activator of transcription 5 (STAT5) promotes proliferation of a wide range of cell types, there are cell-specific and context-specific cases in which loss of STAT5 results in enhanced cell proliferation. Here, we report that