Wnt antagonist gene polymorphisms and renal cancer
β Scribed by Hiroshi Hirata; Yuji Hinoda; Koichi Nakajima; Nobuyuki Kikuno; Soichiro Yamamura; Kazumori Kawakami; Yutaka Suehiro; Z. Laura Tabatabai; Nobuhisa Ishii; Rajvir Dahiya
- Book ID
- 102111813
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 379 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Secreted frizzledβrelated protein 2 (__sFRP2__) is a negative modulator of the Winglessβtype (Wnt) signaling pathway, and shown to be inactivated in renal cell carcinoma (RCC). However, the molecular mechanism of silencing of __sFRP2__ is not fully understood. Our study was designed to
## Abstract The Wnt signaling pathway is activated in most cancers while Wnt antagonist genes are inactivated. However, the functional significance and mechanisms of inactivation of Wnt antagonist Dkkβ3 gene in renal cell carcinoma (RCC) has not been reported. In this study, we examined potential e