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WNT and WISP1 expression in the synovium induces production of cartilage-degrading metalloproteinases by synovial cells

โœ Scribed by van den Bosch, M.H.; Blom, A.B.; Suen, S.W.; van Erp, A.E.; van de Loo, F.A.; Davidson, E.N. Blaney; van der Kraan, P.M.; van Lent, P.L.; van den Berg, W.B.


Book ID
122304610
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
517 KB
Volume
22
Category
Article
ISSN
1063-4584

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Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti