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Withdrawal symptoms from paroxetine

โœ Scribed by Colin Milliken; Stephen J. Cooper

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
74 KB
Volume
13
Category
Article
ISSN
0885-6222

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โœฆ Synopsis

Cessation of tricyclic antidepressant drugs can result in `cholinergic type' withdrawal symptoms. There is also evidence for withdrawal symptoms following sudden cessation of SSRI antidepressants. Observations made on three patients are described following abrupt cessation of paroxetine, prescribed for treatment of depression. The withdrawal symptoms described are suggestive of some form of serotonergic eect and the dierent frequencies with dierent SSRIs may relate to their dierent potencies for serotonin re-uptake inhibition as well as to pharmacokinetic dierences.

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