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Withanolide Compounds from the Flower of Datura metel L.

✍ Scribed by Bingyou Yang; Qiuhong Wang; Yonggang Xia; Weisheng Feng; Haixue Kuang

Publisher
John Wiley and Sons
Year
2007
Tongue
German
Weight
81 KB
Volume
90
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Three new withanolide compounds named baimantuoluoline A (1), B (2), and C (3) and the two known withanolides withafastuosin E (4) and withametelin C (5) were isolated from the fraction exhibiting activity for psoriasis in the flower of Datura metel L. The three new structures were determined as (5__α__,6__α__,7__α__,12__β__,15__β__,22__R__)‐6,7‐epoxy‐5,12,15‐trihydroxy‐1‐oxowitha‐2,24‐dienolide (1), (5__α__,6__β__,15__β__,22__R__)‐ 5,6,15,21‐tetrahydroxy‐1‐oxowith‐24‐enolide (2), and (5__α__,6__β__,12__β__,22__R__)‐5,6,12,21‐tetrahydroxy‐27‐methoxy‐1‐oxowitha‐2,24‐dienolide (3) on the basis of extensive spectroscopic data (HR‐ESI‐MS, ^1^H‐ and ^13^C‐NMR, ^1^H,^1^H‐COSY, HSQC, HMBC, and NOESY) (withanolide=22‐hydroxyergostan‐26‐oic acid δ‐lactone).

📜 SIMILAR VOLUMES

Withanolide Compounds from the Flower of
Withanolide Compounds from the Flower of Datura metel L.
✍ Bingyou Yang; Qiuhong Wang; Yonggang Xia; Weisheng Feng; Haixue Kuang 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 19 KB 👁 1 views

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Baimantuoluolines D – F, Three New Witha
Baimantuoluolines D – F, Three New Withanolides from the Flower of Datura metel L.
✍ Bingyou Yang; Qiuhong Wang; Yonggang Xia; Weisheng Feng; Haixue Kuang 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 German ⚖ 189 KB 👁 1 views

## Abstract Three new withanolide compounds, named baimantuoluolines D–F, along with three known withanolides and a lignan were isolated from the flower of __Datura metel__ L., the parts effective against psoriasis. The structures of the new compounds were elucidated as (5__α__,6__β__,12__β__,20__R

Baimantuoluosides A – C, Three New Witha
Baimantuoluosides A – C, Three New Withanolide Glucosides from the Flower of Datura metel L.
✍ Haixue Kuang; Bingyou Yang; Ling Tang; Yonggang Xia; Deqiang Dou 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 German ⚖ 273 KB 👁 1 views

## Abstract In search for bioactive compounds from the flower of __Datura metel__ L., three new withanolide glucosides, namely baimantuoluosides A, B, and C (**1**–**3**, resp.) were isolated. Enzymatic hydrolysis of **1**–**3** afforded the corresponding aglycones **1a, 2a**, and **3a**, respectiv