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Withaferin A suppresses tumor promoter 12- O -tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells

✍ Scribed by Li, Wenjuan; Zhao, Yunfeng

Book ID
118273472
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
549 KB
Volume
104
Category
Article
ISSN
1347-9032

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✍ Lori R. Bernstein; Rodrigo Bravo; Nancy H. Colburn 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 912 KB

## Abstract Neoplastic transformation and transcriptional activation by activator protein‐1 (AP‐1) complex are stimulated by tumor‐promoting agents in promotion‐sensitive (P^+^) but not promotion‐resistant (P^‐^) mouse epidermal JB6 cells in culture. This implicates AP‐1 as a specific regulator of