✦ LIBER ✦

WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes

✍ Scribed by Malini Sen; Yu-Ho Cheng; Mary B. Goldring; Martin K. Lotz; Dennis A. Carson

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 235 KB
Volume: 50
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.20005

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Regional quantification of cartilage typ

Regional quantification of cartilage type II collagen and aggrecan messenger RNA in joints with early experimental osteoarthritis

✍ John Robert Matyas; Dingqiu Huang; May Chung; Mark E. Adams 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 190 KB 👁 1 views

Biosynthetic response of passaged chondr

Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression

✍ Lee, C. R. ;Grodzinsky, A. J. ;Spector, M. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 208 KB

## Abstract To investigate the potential utility of mechanical loading in articular cartilage tissue engineering, porous type II collagen scaffolds seeded with adult canine passaged chondrocytes were subjected to static and dynamic compressions of varying magnitudes (0–50% static strain) and durati

ESE-1 is a potent repressor of type II c

ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes

✍ Haibing Peng; Lujian Tan; Makoto Osaki; Yumei Zhan; Kosei Ijiri; Kaneyuki Tsuchi 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 448 KB

## Abstract The epithelium‐specific ETS (ESE)‐1 transcription factor is induced in chondrocytes by interleukin‐1β (IL‐1β). We reported previously that early activation of EGR‐1 by IL‐1β results in suppression of the proximal __COL2A1__ promoter activity by displacement of Sp1 from GC boxes. Here we

Turnover of type II collagen and aggreca

Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: Relationship to mediators of systemic and local inflammation

✍ Alexander Fraser; Ursula Fearon; R. Clark Billinghurst; Mirela Ionescu; Richard 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB

TNFα suppresses link protein and type II

TNFα suppresses link protein and type II collagen expression in chondrocytes: Role of MEK1/2 and NF-κB signaling pathways

✍ Cheryle A. Séguin; Suzanne M. Bernier 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 413 KB

## Abstract Tumor necrosis factor α (TNFα) inhibits matrix synthesis by chondrocytes in rheumatoid arthritis and osteoarthritis; however, the underlying signaling pathways are poorly characterized. This study investigated the TNFα‐activated pathways regulating expression of two key components of th

gp49B1 deficiency is associated with inc

gp49B1 deficiency is associated with increases in cytokine and chemokine production and severity of proliferative synovitis induced by anti-type II collagen mAb

✍ Joseph S. Zhou; Daniel S. Friend; David M. Lee; Lin Li; K. Frank Austen; Howard 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 366 KB

## Abstract Mice with a disrupted gp49B gene, which encodes gp49B1 that is expressed on certain hematopoietic cells and has two immunoreceptor tyrosine‐based inhibitory motifs (ITIM), exhibit augmented FcϵRI‐initiated mast cell degranulation and resultant tissue edema. gp49B1‐deficient (__gp49B^–/–