Wirkung von Distamycin A und Netropsin auf normale und zellwandlose Zellen von Escherichia coli W1655F+

✍ Scribed by Dr. Edith Schuhmann; Ina Haupt; H. Thrum; U. Taubeneck; Ursula May

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 435 KB
• Volume: 14
• Category: Article
• ISSN: 0233-111X
• DOI: 10.1002/jobm.19740140407

✦ Synopsis

Abstract

Distamycin A and netropsin are basic oligopeptide antibiotics. Though the chemical structure of both antibiotics is very similar, the action on grampositive and gramnegative bacteria is quite different. Distamycin A acts only on grampositive bacteria, while netropsin inhibits grampositive as well as gramnegative bacteria.

Our experiments with the normal rod form and the stable protoplast type L‐form of E. coli W1655F^+^ have shown that distamycin A inhibits gramnegative bacteria to the same extent as netropsin, when wall‐less L‐form‐ells were used. The normal rod cells were inhibited by netropsin only. That means that the wall prevents the penetration of distamycin A as reported earlier for the macrolid antibiotics, actinomycin C and kirromycin.