Wirkung von Dermatocorticoiden auf die Aktivität der hepatischen Tryptophanpyrrolase beim Meerschweinchen

✍ Scribed by Wolfgang Albrecht; Josef K. Longauer; Erich G. Weirich

• Publisher: Springer-Verlag
• Year: 1979
• Tongue: English
• Weight: 634 KB
• Volume: 265
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00412384

✦ Synopsis

The enzyme activity of tryptophane pyrrolase in guinea pig liver can be measurably increased -as in other mammalian species -by systemic administration ofcorticoids, but this effect is short-lived and achieved only with high s.c. doses of, e.g., prednisolone (Ultracorten-H-hydrosoluble). In contradistinction and rather surprisingly the enzyme activity is variably but markedly reduced by high-dosed and protracted epicutaneous application (10 times within 2 weeks) of the well-known dermatocorticoids: hydrocortisone, fluocinolone acetonide, and clobetasol propionate. This reaction must be explained by the capacity of these corticoids to inhibit, after their percutaneous absorption, the functional axis pituitary -adrenal cortex -liver, the stimulatory role of which is mandatory for the endogenous basic activity of hepatic tryptophane pyrrolase.